In this article, we have researched the temporal effects of heart failure on the renal tubules and glomerular function to better optimize the therapy of patients with cardiorenal syndrome.

It is known that kidney function acts as a “barometer” of the severity of heart failure. However, because of the multifactorial nature of the cardio-renal syndrome, merely assessing the glomerular function may be suboptimal for decision-making.

Our study provides evidence for the notion that each aspect of the kidney (glomerular and tubular) shows an incremental prognostic information, and together they may further identify higher-risk individuals with heart failure.

Based on our findings, we also speculate that “renoprotective” treatment targeted at the renal tubules may be even more effective than treatment simply aiming at improving only eGFR or Cr values. These kidney-specific signals may therefore help physicians to better and timely target medical therapy before the future event occurs.

To find out more about this study you can click here.